Our laboratory is part of the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital, Harvard Medical School. We are interested in creating close rodent models of neurodegenerative diseases to understand neuronal injury during aging at the molecular, cell biological and functional level.
Dr. Nuber and co-workers generated and deeply characterized the first inducible α-synuclein transgenic mice and full-length BAC-wild-type α-synuclein rat models of Parkinson’s disease (PD). Her research included the interaction of α-synuclein with synphilin or calpain as well as PD neurotoxins (MPTP, paraquat) in culture models and in double-transgenic mouse brain. She now focuses her research to unique mice based on tetramer-abrogation that closely mimic Parkinson’s disease pathology including L-DOPA responsive motor phenotypes. She and her colleagues published the findings of the PD or DLB models in > 30 peer-reviewed articles.
The laboratory is set to understand mechanisms by which α-synuclein produces PD. We use a wide range of methods, including protein biochemistry, immunohistochemistry, light-, confocal and electron microscopy and test for changes in motor and cognitive behavior.